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KMID : 0616620090150020051
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Journal of Soonchunhyang Medical College
2009 Volume.15 No. 2 p.51 ~ p.58
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Applications of Peptide Nucleic Acid (PNA) in the Biomedicine
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Jung Dong-Jun
Choi Young-Jin
Kim Chang-Jin
Jeong Yu-Jun
Mu Wenxia
Park So-Young
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Abstract
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Peptide nucleic acid (PNA) are synthetic mimics of nucleic acids in which the deoxyribose phosphate backbone is replaced by a flexible pseudo-peptide polymer to which the nuclear bases are linked. This structural properties enable PNAs to hybridize with high affinity and specificity to complementary sequences of DNA and RNA, They also confers remarkable resistance to DNAses and proteinases, Over the last few years, several exciting new applications of PNA technology has been published in the biomedicine of genetics, cytogenetics and viral diagnostics. PNA-based hybridization technology is developing rapidly in the field of in situ hybridization as well,
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KEYWORD
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Peptide nucleic acid, Nucleic acid
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